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UK
October 18, 2018

UK platelet researchers attend 4th EUPLAN meeting in Bruges

4th EUPLAN Conference – Report by Dr Sarah Jones, Manchester Metropolitan University

The European Platelet Network recently hosted the 4th EUPLAN meeting (19th-21st September 2018) in the beautiful city of Bruges, Belgium. The meeting focused on platelets in thrombosis and beyond, with keynote lectures on thrombopoeisis, the role of platelets in inflammation and infection, platelet contributions to Alzheimer’s disease and the potential of platelets as a platform for cancer diagnostics. It was a stimulating meeting with significant contributions from early career researchers and a strong representation from the UK platelet community, with over 40 UK delegates from 14 different institutions.

The meeting opened with a welcome address from chair of the organising committee Prof Hans Deckmyn, before keynote lectures from Dr Emma Lefrançais (University of Toulouse) presenting the highlights from her recent work published in Nature, on platelet production in the lungs, and Dr Dominique Baruch (INSERM UMR-S 1140), who gave an excellent overview of ex-vivo platelet production. The welcome reception then preceded at City Hall, an impressive Gothic building in the heart of Bruges built between 1376 and 1421.

The second day of the meeting started with keynote lectures from Dr Benoit Ho-Tin-Noe (INSERM Unit 1148), who discussed the importance of platelets in preventing bleeding and showed evidence to suggest that platelets are recruited to sites of neutrophil infiltration to repair the gaps in the vascular endothelium. Dr Julie Rayes (University of Birmingham) followed with a keynote lecture on Platelet ITAM receptors and their role in inflammation. Dr Rayes elegantly highlighted the divergent role of GPVI and CLEC-2 in inflammation, despite sharing a common signalling pathway and presented evidence on the beneficial role of impaired vascular integrity in tissue repair.

There were also ten short oral communications including a presentation from Dr Markus Bender (University Hospital Wuerzburg), suggesting that platelet lamellipodia were not required for thrombus stability, stimulating interesting discussion; and Dr Giordano Pula (University of Exeter) describing platelet dependent angiogenesis and repair mechanisms via platelet derived deoxyriobose-1-phosphate.

The day concluded with a keynote lecture from Dr Illaria Cannobio (University of Pavia), summarising her work on the toxicity of amyloid peptides in the circulation and the role of platelets in the link between cardiovascular disease and Alzheimer’s disease. Delegates then had the opportunity to take in the beautiful sights of Bruges with a boat trip along the canals before the conference dinner at the Half Moon Brewery.

The final day of the meeting started with a keynote lecture from Dr Olivier Peyruchaud (INSERM U1033), who presented data demonstrating crosstalk between platelets and cancer cells via cysteinyl leukotrienes (Cys-LKT) and the CystLT1 receptor. This was followed by a keynote from Dr Cecile Oury (University of Liege) who gave an interesting insight into the potential role of platelets in propagating a microenvironment, which drives tumourogenesis through bridging haemostatic and inflammatory signals. Short communications included a presentation from Dr Judith Cosemans (Maastrict University) on the differential effects of PDE3 and -5 on platelet function under haemostatic and inflammatory conditions, and a presentation from Jo Mitchell (University of Reading) on platelet-specific factor XIIIa.

In addition to the oral presentations, vibrant discussions and debates were stimulated in the poster sessions, which were split over two days. There were over 80 posters on display, presenting high quality research on a diverse range of topics including novel diagnostic assays, novel platelet function assays, the impact of antiretroviral therapy on platelet activation, reactive oxygen species production in platelets and hyperlipidaemia and platelet function to name a few.

The meeting was a wonderful celebration of the fantastic and diverse platelet research currently underway across Europe, an ethos that is set to continue with the 5th EUPLAN meeting planned for 2021, in Milan hosted by Prof Marco Cattaneo and Prof Mauro Torti.

Congratulations to Hull PhD Researcher on passing viva New Platelets journal cover image announced

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Did you know that the platelet society advertises platelet and megakaryocyte related jobs? Currently on the website we have post doc, PhD studentship, fellowship and Masters opportunities available! #platelets

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We are pleased to announce the 1st full meeting of the Platelet Society will be held on 12th–13th September 2019 in the historic setting of Jesus College, Cambridge. Details for registration and abstract submission will be available soon. #Platelets

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Happy New Year! What better way to start the year than to promote the success of our members who have received grant funding, and have positions available? @RdgPlateletLabs has a PhD Studentship in Biomedical Sciences/Biomedical engineering .....

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2 months ago

The Platelet Society

As the song goes...we wish you a merry Christmas and happy New Year! Thanks for all your support in developing the new Platelet Society and we hope to continue onward and upwards next year! #Platelets #plateletresearch #MerryChristmasEveryone ... See MoreSee Less

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Platelet Society members attend bioinformatics workshop

In September, Platelet Society members attended the Genomics Workshop in Cambridge. Alex Bye, from the University of Reading, has written a short report on the meeting, which details the fantastic opportunity attendees had to learn cutting-edge techniques for genomic analysis directly from researchers that are using and developing them.

plateletsociety.co.uk/news/platelet-society-members-attend-bioinformatics-workshop/
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Platelet Society members attend bioinformatics workshop

In September, Platelet Society members attended the Genomics Workshop in Cambridge.  Alex Bye, from the University of Reading, has written a short report on the meeting, which details the fantastic opportunity attendees had to learn cutting-edge techniques for genomic analysis directly from researchers that are using and developing them. 

https://plateletsociety.co.uk/news/platelet-society-members-attend-bioinformatics-workshop/Image attachment
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The Platelet Society

4 months ago

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New Platelets journal cover image announced!

The Platelets journal www.tandfonline.com/loi/iplt20 recently ran their annual cover image competition which will feature on the cover of the journal for the whole of 2019. Several Platelet Society members entered stunning images, but the final winners were Nathan Eaton and Hervé Falet from the Blood Research Institute (Wisconsin) for their stunning image “Platelet Fireworks”, showing Dnm2-null platelets on a fibrinogen surface after GPVI activation.

Well done to Nathan and Hervé.

Look out for the call to enter in 2019! #Platelets
... See MoreSee Less

New Platelets journal cover image announced!

The Platelets journal https://www.tandfonline.com/loi/iplt20  recently ran their annual cover image competition which will feature on the cover of the journal for the whole of 2019. Several Platelet Society members entered stunning images, but the final winners were Nathan Eaton and Hervé Falet from the Blood Research Institute (Wisconsin) for their stunning image “Platelet Fireworks”, showing Dnm2-null platelets on a fibrinogen surface after GPVI activation.

Well done to Nathan and Hervé.

Look out for the call to enter in 2019! #Platelets
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The Platelet Society

4 months ago

The Platelet Society

Platelet Society Members and UK platelet researchers attended the 4th EUPLAN meeting in Bruges in September 2018.

Read the report by Dr Sarah Jones, (Manchester Metropolitan University) which details the focus of the meeting & an overview of the talks. The meeting was a great success!

plateletsociety.co.uk/news/uk-platelet-researchers-attend-4th-euplan-meeting-in-bruges/
... See MoreSee Less

Platelet Society Members and UK platelet researchers attended the 4th EUPLAN meeting in Bruges in September 2018.

Read the report by Dr Sarah Jones, (Manchester Metropolitan University) which details the focus of the meeting & an overview of the talks. The meeting was a great success!

https://plateletsociety.co.uk/news/uk-platelet-researchers-attend-4th-euplan-meeting-in-bruges/
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The Platelet Society was celebrating success.

4 months ago

The Platelet Society

Many congratulations to Jawad S. Khalil, PhD student at the University of Hull with Francisco Rivero and Khalid Naseem, who passed his PhD viva on the 3rd October. His thesis entitled “A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets” was examined by Dr. Steve Thomas (U. of Birmingham) and Monica Arman (U. of Hull).

Well done Jawad from the Platelet Society, and good luck in your future career!
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