Postdoctoral Research Fellow in Immunothrombosis

We seek an enthusiastic individual with a strong interest and background in cardiovascular sciences and/or immunology to work in the laboratory of Professor Nicola Mutch & Dr Claire Whyte. The successful candidate will join a well-funded, dynamic research group within the Institute of Medical Sciences.

Immunothrombosis is considered to be a driver of thromboinflammation in acute infection, such as COVID-19 or sepsis. However, the mechanisms by which immunothrombosis drive coagulopathy remain unclear. Despite recent advances in the development of antithrombotic strategies, these demonstrate limited efficacy in targeting immune-driven coagulopathy. This is possibly due to alternative activation of coagulation and dysregulation of fibrinolysis, seen in the inflammatory state, compared to classical haemostasis and thrombosis models. Indeed, cardiovascular conditions such as deep vein thrombosis (DVT) and atherosclerosis are now recognised as prototypical forms of sterile immunothrombosis, commonly referred to as thromboinflammation, in which the activation of the innate immune system occurs in the absence of infection. This exciting project will investigate novel interactions of the fibrinolytic system and the innate immune system to unpick the cross-talk between these two pathways.

For more information, please email n.j.mutch@abdn.ac.uk

Closing date 10/12/2024