Two Post-Doctoral Scholar positions are available immediately in the Platelet Program within Skip Brass’s laboratory at the Perelman School of Medicine of the University of Pennsylvania for NIH-funded studies on platelet and vascular biology. The Brass lab uses a combination of cell biology, mouse models, computational models, and in vivo imaging to answer basic and applied questions about hemostasis, thrombosis, cell signaling, and the role of platelets in maintaining vascular integrity. The Platelet Program exists within a vibrant community of investigators at Penn and Children’s Hospital of Philadelphia with shared interests (and research) in platelet, coagulation factor and vascular biology. Participating laboratories meet weekly and share an NIH HLBI T32-funded training program.

Recent publications containing our work include the following.

• Gupta, C. Konradt, A. Corken, J. Ware, B. Nieswandt, J. DiPaola, M. Yu, D. Wang, M.T. Nieman, S.W. Whiteheart and L.F. Brass, Hemostasis vs. Homeostasis: platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. PNAS 117: 24316-24325, 2020.
• DJ DeHelian, S. Gupta, J. Wu, CL Thorsheim, B. Estevez, M. Cooper, K. Litts, M.M. Lee-Sundlov, K. Hoffmeister, M. Poncz, P. Ma, LF Brass. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. Blood 2020. DOI: 10.1182/blood.2019003251. PMID: 32542378.
• Poventude-Fuentes, K.W. Kwon, J. Seo, M. Tomaiuolo, TJ Stalker, LF Brass and D. Huh. A Human Vascular Injury-on-a-Chip Model of Hemostasis. Small 2020. PMID: 33150735 DOI: 10.1002/smll.202004889
• Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ. Interrelationships between structure and function during the hemostatic response to injury. PNAS 116:2243-2252, 2019. PMID: 30674670

Interested candidates should send their CV, references and a paragraph describing their career plans to brass@pennmedicine.upenn.edu. Questions are also welcomed. Trainees who are U.S. citizens or permanent residents will also be considered for appointment to the Hematology Research Training Program (T32 HL07439). Prior experience working with platelets and/or endothelial cells would be helpful, as would experience with mouse models of any kind.

Lawrence (Skip) Brass, MD PhD

Professor of Medicine and Pharmacology

Division of Hematology-Oncology

University of Pennsylvania Perelman School of Medicine

Philadelphia, PA (site of the 2021 ISTH Conference)

brass@pennmedicine.upenn.edu