WebsiteManchester metropolitan Univeersity
3 year British Heart Foundation funded studentship
Platelet-driven thrombosis continues to account for high levels of mortality worldwide. In diseases associated with increased platelet function and increased risk of thrombosis, endothelial dysfunction is a prominent feature, yet there is a lack of therapeutic approaches which directly target the thrombotic phenotype of endothelial cells.
The aim of this study is to elucidate the fundamental role of Pim kinase, a novel anti-thrombotic target, in regulating endothelial cell function and assess the ability of Pim kinase inhibitors to preserve the anti-inflammatory and antithrombotic properties of endothelial cells.
The successful student will join the Thrombosis research group and Cardiovascular Theme in the Centre for Bioscience at Manchester Metropolitan University, supervised by Dr Amanda Unsworth, Dr Sarah Jones and Dr Steve White. The group has expertise in endothelial cells, platelets, megakaryocytes, genomics and microscopy, and the student will be trained in a wide range of general and field specific techniques. Including cell culture, flow cytometry, fluorescent microscopy, ELISAs and Western blotting, as well in vitro thrombus formation assays. The student will also be trained in performing transcriptomics analysis, including sample preparation and data analysis of large data sets.
Specific requirements of the project
Applicants should have a strong background in Cellular and Molecular Biology, and ideally a background and interest cardiovascular biology and thrombosis. Experience of cell culture, gene expression and fluorescence microscopy is advantageous. They should have a commitment to translational science research and hold or expect to obtain at least an Upper Second Class Honours Degree in Biomedical Sciences, Biochemistry, Biology, or other relevant subject.
To apply for this job please visit www.mmu.ac.uk.