Project title: Study of the mechanisms and actions of new medication to prevent thrombosis
Supervisors: Prof Jon Gibbins, Dr Dan Kennedy and Dr Chris Jones
Project Overview: Platelets perform a pivotal role in the regulation of blood clotting, a physiological response to injury that prevents excessive bleeding. They also play a central role in thrombosis, the inappropriate formation of blood clots in the circulation that lead to heart attacks and strokes.
In this study we will explore newly identified or developed molecules that modulate platelet function to determine how these may be used to reduce platelet activation and risk of thrombosis. We will explore the mechanisms of action of these drugs and determine whether these mechanisms are shared with other cell types and biological processes in the control of, for example inflammation, virus-induced thrombosis and cancer. This will provide new avenues for the prevention of thrombosis and other serious conditions in which platelets are implicated.
The project which is sponsored by Quercis Pharma will involve training in the use of a wide range of cell and molecular biology techniques, and specialist analysis of blood cell function. The study will include the use of animal models of thrombotic disease, and techniques that allow high throughput analysis of cell function. You will be trained in the development of experimental plans, data collection and analysis, which may include mathematical/computational (machine-learning) approaches to characterise platelet function.
The successful candidate will join the Reading Platelet Biology Group, an internationally recognised research team comprising in-excess of 25 researchers. This will provide a stimulating and exciting environment in which to learn, and access to a wide range of research ideas, and state-of-the-art facilities. You will discuss your work at weekly research group meetings, attend our journal club, and present your research at national and international research conferences. Opportunities will be provided to spend time with colleagues at Quercis Pharma to gain experience of the drug development in the pharmaceutical sector, and associated business development.
Applicants should hold or expect to gain a minimum of a 2:1 Bachelor Degree or equivalent in a biomedical field of study or a strongly-related discipline. Applicants will also need to meet the University’s English Language requirements. We offer pre-sessional courses that can help with meeting these requirements.
- Starts 20th September 2021
- 4 year award
- Funding covers full UK tuition fees plus a maintenance allowance of £20,000pa