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One of our goals at The Platelet Charity is to provide information on PFDs for sufferers, carers and the medical profession.
We will do this through a series of resources such as this website, information sheets and patient awareness talks across the country.
Please click here for the library of resources available. We will be adding to this on a continual basis, so please check back soon.

Human Platelet

Q: What do platelets look like ?

The 2 pictures on the right are photo-micrographs of a single Human Platelet
A. Human platelet with multiple storage compartments (yellow arrowheads). These storage compartments contain proteins that are released at the site of injury once platelets are activated and contribute to the formation of a platelet plug.
B. Human platelet from a patient with ARC syndrome that lacks the above storage compartments. Platelets from those patients are unable to form a stable plug resulting in mild bleeding. (500nm =  500 billionths of a metre)

Q: Are Platelet Function Disorders (PFD) related to haemophilia?

Haemophilia is not a PFD. It is caused by the loss of a clotting factor (factor 8). The inheritance of haemophilia means that women are “carriers” but do not normally have excessive bleeding, and only men are affected. . Both haemophilia and PFDs cause excessive bleeding, but the bleeding in haemophilia is typically into joints rather than the symptoms of PFDs described here.

Q: Are Platelet Function Disorders related to thrombosis

Thrombosis refers to the formation of life-threatening blood clots which can lead to conditions such as heart attack, stroke and pulmonary embolism. Platelets are involved in many types of thrombosis. However, they are not considered to be platelet function disorders as they are associated with normal or excessive platelet function, rather than a loss of platelet function.

Q: What treatments are there for Platelet Function Disorders?

There are a small number of treatments for PFDs which should be discussed with your haematologist . These include drugs such as DDAVP (which can be given via nasal spray or under the skin) and tranexamic acid (which can be given as a tablet or into the vein). Both of these medications don’t cure PFDs but help to strengthen and stabilise blood clots. In rare cases blood transfusion can be considered, although this is only used if absolutely necessary. .

Q: How many researchers are working in developing treatments for Platelet Function Disorders?

There are many people working on platelets in the UK and throughout the world, but only a minority of these are working on platelet function disorders, in part because of the lack of funding. Testing platelet function is complicated and this also makes research into this area difficult. One of the aims of the charity is to encourage new ideas and new approaches in diagnosing and treating PFDs from laboratories who are currently investigating other aspects of platelet function.